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Protein Crystallography in Drug Discovery
Robert E. Babine (Editor), Sherin S. Abdel-Meguid (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor)
Publisher: John Wiley & Sons Inc
Protein Crystallography in Drug DiscoveryBiochemistry

The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method.

Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included.

A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.


Table of Contents
Book Protein Crystallography in Drug Discovery

$193.00  
Format Hardcover
Medium Paper
ISBN 3527306781
Copyright Year 2004
Length 278 Pages
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