RAmEx Ars MedicaWorld's most comprehensive source of CD-ROMs, videos, slides and books for medical professionals.
About UsContactShopping CartOrder StatusHelpHome
Title Details
Assessing Bioavailablility of Drug Delivery Systems: Mathematical Modeling
Jean-Maurice Vergnaud, Universite de Saint-Etienne, France; Iosif-Daniel Rosca, Polytechnic University of Bucharest, Romania
Publisher: CRC Press
Pharmacology

  • Presents the latest mathematical methods for modeling the bioavailability of drugs from controlled release dosage forms
  • Elucidates the mathematics in a clear and understandable manner through diagrams and nomographs
  • Provides insight into underlying chemical reactions and physical mass transfer processes
  • Includes case histories for controlled-release dosage forms and immediate-release dosage forms
  • Examines the relationship between the dosage form design and plasma drug levels
  • Supplies a useful platform for further investigations of the pharmacodynamic agents, particularly in the environment of increased drug resistance and drug-drug interactions
Exploring how to apply in vitro/in vivo correlations for controlled release dosage forms, Assessing Bioavailability of Drug Delivery Systems: Mathematical Modeling clearly elucidates this complex phenomena and provides a guide for the respective mathematical modeling. The book introduces mathematical modeling methods for calculating the profiles of plasma levels obtained with controlled release dosage forms and provides examples and case studies to illustrate the techniques employed.

The author has considerable experience in investigating mathematical fundamentals that are related to pharmaco- and toxicokinetics, modified-release drug products, physiologic pharmacokinetics and statistical treatment in clinical situations. The mathematical models he has developed are particularly powerful because they account for such major parameters as the kinetics of drug release controlled by diffusion or by erosion, and the kinetics of absorption into and elimination out of the plasma. They are also able to solve the problem of determining the drug level in plasma as a result of patient non-compliance, incorrect dosage, and incorrect frequency and to determine the best dosage forms necessary for therapy.

Using master curves, the book highlights the inter-variability of the patients often expressed by different responses towards a drug. Thus, after evaluating a patient's pharmacokinetic parameters, the dose can be adapted to the patient, with the expectation of decreasing the side effects for each patient. Using dimensionless numbers in repeated doses, either for the time or for the plasma drug concentration, makes the master curves useful for every drug, providing that its pharmacokinetics was linear. These master curves address clear information either to the patients or to the therapists in a didactic and easy way. The patients can see from first look the effects of non-compliance and therapists can see the dramatic effects of inter-variability of patients towards a drug.

Drug discovery and dosage forms have become an increasingly time-consuming and expensive process. The development of a single drug can leave behind more than 10 to 15 years of work. Discussing time and cost-effective methods as alternatives to conventional in vivo methods, the book helps you analyze and integrate in vitro/in vivo correlations and apply them to patient care and drug consultation situations.


Table of Contents
Book Assessing Bioavailablility of Drug Delivery Systems: Mathematical Modeling

$185.00  
Format Hardcover
Medium Paper
ISBN 0849330440
Copyright Year 2005
Length 248 Pages
Back to Top
Featured Products
Acland's Video Atlas of Human Anatomy
Stedman's Plus 2002 Medical/Pharmaceutical Spellchecker Win/Mac CD ROM Nursing 2003 Drug Handbook (Springhouse) The Works of Frank H. Netter MedTerms Illustrated USMLE; Step 1,2,3 Drug Topic Red Book


RAmEx Ars Medica, Inc. | 1714 S. Westgate Av. #2 | Los Angeles, California 90025-3852 | USA
International: 1 310 826 4964 | In the USA: 1 800 633 9281 | Fax: 1 310 826 9674
email ramex.com


Advanced Search
Search By Publisher
Search By Specialty
Search By Media
Search By Title
Shopping Cart
Your Cart is Empty
Home | About | Help | Contact | Policy | Shopping Cart | Order Status
Advanced Search | Publishers | Specialties | Media | Title | RMA | Site Map
2017 RAmEx Ars Medica, Inc.

RAmEx Ars Medica, Inc. is a distributor of Scientific Technical Engineering Medical Reference Books Software Videos Online Courses Computers Medical Supplies ramex.com SALE DISCOUNT LOWEST PRICE CLEARANCE

RAmEx Ars Medica, Inc. is a distributor of Scientific Technical Engineering Medical Reference Books Software Videos Online Courses Computers Medical Supplies ramex.com SALE DISCOUNT LOWEST PRICE CLEARANCE

RAmEx Ars Medica, Inc. is a distributor of Scientific Technical Engineering Medical Reference Books Software Videos Online Courses Computers Medical Supplies ramex.com SALE DISCOUNT LOWEST PRICE CLEARANCE

RAmEx Ars Medica, Inc. is a distributor of Scientific Technical Engineering Medical Reference Books Software Videos Online Courses Computers Medical Supplies ramex.com SALE DISCOUNT LOWEST PRICE CLEARANCE