The Merck Manual has set the standard for excellence in professional medical information since it was first published in 1899. The Centennial Edition has been redesigned to enhance readability and features more changes than any other edition in the past 20 years. New topics include Smoking Cessation, Chronic Fatigue Syndrome, Rehabilitation, and Drug Therapy in the Elderly.

The Merck Manual is celebrating its centenary with the publication of the 17th Edition. The Merck Manual is used by more medical professionals worldwide than any other general medical textbook and has been continuously published longer than any other English language general medical textbook.