This is clinically sophisticated, easy-to-use medical software that helps counseling physicians reliably predict a subfertile couple's chances of achieving spontaneous conception or live birth with the aid of treatments using clomiphene, intrauterine insemination (IUI), IUI combined with controlled ovarian hyperstimulation (COH), in vitro fertilization (IVF), or IVF with intracytoplasmic sperm injection (IVF-ICSI). The program uses a combination of validated prognostic models and reference-based calculations to produce exceptionally reliable estimations of chances for conception, based upon simple input of a limited set of data for the couple. PROGNO is the only software program that makes these exceptionally complex calculations available for direct, easy application to clinical practice. Buyers receive a floppy disk containing the Windows™-based software, a Handbook, and a User's Manual.