• Edited by pioneers in the field, this guide
• highlights the most recent applications, techniques, and technologies that may enable researchers to tailor drug treatment regimens to individual patients with the aid of genomic information
• considers not only individual differences in susceptibility to adverse drug effects, but genetic differences in drug efficacy
• uses a multitude of examples to clarify gene-drug interactions
• examines the role and mechanisms of drug metabolism, receptors, transporters, ion channels, interethnic differences, and regulatory components as seen from an FDA perspective
• presents modern approaches to gene expression and its detection via serial analysis and microarrays

Reflecting the shift from genetics to genomics in the pharmaceutical sphere, this Second Edition traces the evolution of the science of pharmacogenetics and gathers research from the forefront of the field-spanning the most influential breakthroughs in molecular diagnostics, metabonomics, proteomics, bioinformatics, disease mapping, pharmacodynamics, and disease gene identification.