This extensively revised and expanded second edition incorporates the knowledge gained from the widespread implementation of large rt-PA for acute stroke trials and demonstrates the power of the new technologies now available. The authors have included much new material on stroke-MRI and computed omogaraphy, and updated all chapters describing the background, use, and nuances of thrombolytic therapy. They present everything one needs to know for proper patient selection, the key to successful treatment. Practical how-to chapters guide the reader in treating acute stroke patients, both with and without thrombolytic therapy. New detailed practice cases that simulate making the rounds in a world-class stroke center prepare practitioners to be as ready as possible for their first case.