The past decade has witnessed tremendous progress in psychiatric neuroimaging research. Investigators have developed, in tandem with significant advances in imaging technology, innovative strategies for exploiting the awesome potential of these new tools.

This volume brings you up to date on the latest developments by providing insight into the methodology of experimental design of the numerous neuroimaging articles being published in today’s peer-reviewed journals. Revealing the remarkable wealth of neuroimaging’s potential contributions to psychiatry, 49 distinguished contributors use accounts of their own research to illustrate the power of particular paradigmatic techniques. These techniques hold promise not only for delineating pathophysiology and advancing neuroscience, but also for yielding discoveries of direct clinical significance, such as diagnostic testing, predictors of treatment response, and new medications.

Focused specifically on applications in psychiatry, these chapters are uniquely organized around experimental paradigms rather than psychiatric disorders:

• Using magnetic resonance imaging (MRI) to detect and characterize subtle, easily overlooked abnormalities in schizophrenia and schizotypal personality disorder.
• Testing specific hypotheses regarding the functional integrity of implicated neural systems within the brain as part of cognitive activation studies of schizophrenia and obsessive-compulsive disorder (OCD).
• Assessing the roles of the amygdala and striatum in anxiety disorders, including masked stimuli and other task manipulation methods to assay nonconscious brain activity.
• Investigating the neural correlates of psychiatric symptoms in anxiety disorders, using script-driven imagery and in vivo exposure to experimentally manipulate study conditions.
• Capturing the often elusive symptoms of hallucinations and psychomotor tics using innovative imaging techniques.
• Using transcranial magnetic stimulation (TMS) to investigate how the brain regulates mood.

Other fascinating topics include using positron emission tomography (PET) and single photon emission computed tomography (SPECT) to discern the therapeutic mechanisms of psychotropic medications and enhance the development of new medications; integrating structural and functional imaging to treat major depression; using magnetic resonance spectroscopy (MRS) to quantify brain concentrations of exogenous compounds; using MRI to visualize circuits implicated in developmental disorders such as attention-deficit/hyperactivity disorder (ADHD) and anxiety, including ground-breaking studies of children; using functional MRI in animals and its applications in psychiatric research; and exploring the use of neuroimaging methods to investigate genetic contributions to normal cognitive function.

Specialists and general clinicians alike will find much of interest in this definitive look at the exciting developments in neuroimaging today and how they can enhance our understanding and treatment of psychiatric disorders. This comprehensive text with its extensive illustrations and annotations will also prove a welcome addition to any course in the neurosciences.

Reviews
“As a psychiatrist involved in the field of psychiatric neuroimaging, I found this book to be an invaluable resource. Within these pages, the reader will be introduced to the work of some of our field's most reputable investigators. Its focus on methodologies and research paradigms is also a welcomed change from the usual direction towards specific disease entities. The discussions on experimental design and techniques are thorough and informative. I recommend this reference to anyone who is interested in learning what is possible in the field of psychiatric neuroimaging.”—Stephen M. Delisi, M.D., Rush-Presbyterian-St. Luke's Medical Center, Doody Publishing

“…[T]he authors have succeeded admirably in providing a window on some of the exciting advances already achieved, the questions yet to be addressed, and the though process behind the complexities of neuroimaging research. It is highly recommended for both researchers and nonresearchers who would like to learn more about this challenging but invaluable field.”—Rhoshel Lenroot, M.D., American Journal of Psychiatry

“This book is a valuable reference for psychiatrists who want an update on neuroimaging findings in schizophrenia, depression, anxiety, and other psychiatric disorders, or who merely want to improve their ability to understand the psychiatric neuroimaging literature.…Finally, with the emphasis on paradigms and experimental design, this book is an excellent starting point for students and fellows beginning research in clinical neuroimaging.”—Joseph D. Pinter, M.D., Journal of Nervous and Mental Disease, September 2002